A truly optimal run is rolling like 6 12s in a row with holo dice, then just sailing through everything.
My current run strategy as a pretty poor man is
1. Pull and eat 3 AHs, pull and equip token bling(being lent to me by sally)
2. adventure in park until ant quest and cage quest are done (take lots and lots of wishes), equip ant queen claw/crown
2a. when finished with cage quest, equip rubber ducky, remove and autosell elephant and giraffe equips
2b. buy 3 cider spiders from jazzycat when able to afford, drink when transitioning between areas when the intoxication will help
3. pull strap on wings, adventure in junkyard until I get a cuddly trash can, equip it, always end up with buff beer to finish off bladder
4. adventure in woods until I get 2 wooden rings, if I get a wooden jug, cool, if not who cares
Day 1 typically ends here
5. pull and eat 3 AHs, buy 3 cider spiders
6. adventure in second-hand sideshow until I get stilts and beard, equip both, will end up with some short pills too
7. use intoxication/short pills to go to mine camp f for fishnet stockings, equip
8. adventure in sideshow/mine camp(if possible) until level 7
9. At level 7 adventure in the lab that starts with a u until you get the keycard and get bravado on every noncombat(beard helps)
Day 2 ends
10. keep getting bravado until average lab enemies are dealing 10-15 damage, then kill star-crossed scientist and shifty company guy with really bad jokes, then get the last card from the armchair
11. Take out legion with 2 really bad jokes, throw huge party, invite everyone
Gets me solid 3 days that are somewhat close to 2 days (don't have to eat or drink on day 3 to finish) I know this is far from optimal, but it's the best way to do runs that I've figured out with my available resources. I end up spending shitloads on burn cream though, going to the labs before I can survive combat at all. I'd probably be slowed down to 4 days if it weren't for really bad jokes, almost definitely slowed to 4 days if it weren't for the bling, and probably slowed to 5 or 6 if I didn't have either, so yeah, right now it pretty much just takes a lot of expensive stuff to reset fast. Come beta, I'm hoping the skills and new mechanics will make speed reseting more skill based than stuff based, or at least there's a version of ToG's hardcore mode, where regenerating anything is impossible, so it comes down entirely to skill and RNG luck